SB II:1 pre

Öppen, randomiserad fas-III regional multicentrisk studie

Sydsvenska Bröstcancergruppen

Max 12 mån efter sista menstruation
Stadium T1b-2bN0, T0N1, T1-2bN1
Modifierad radikaloperation med axillutrymning

Strålbehandling

Strålbehandling + Sendoxan 130 mg/m2 x 1, dag 1-14, 12 cykler

Sendoxan 130 mg/m2 x 1, dag 1-14,
12 cykler

1 Frekvens och typ av recidiv
2 Recidivfri överlevnad
3 Totalöverlevnad

Arwidi Å, Aspegren K, Augustsson N-E, Hafström Lo, Norgren A, Svahn-Tapper G: Postoperative radiation therapy in mammary carcinoma stage II. Acta Radiol Oncol 1979;18:273-281.

Hafström LO, Lindberg L G, Mulow A, Möller T, Norgren A, Rydén S, Westrup C, Widmark H, Wiklander O: Rapport - Adjuvant behandling av bröstcancer stadium II. Två års erfarenhet av en regiontäckande multicenterstudie. Onkologiskt centrum; Lund 1980.

Rydén S, Aspegren K, Hafström Lo, Möller T: Evaluation of 162 surgeons' technique of operating breast cancer. Proc II. Congreso Internacional de Senologia, Barcelona 1981.

Rydén S, Gullberg B, Hafström Lo, Möller T, Widmark H: Är skelettscintigrafi vid uppföljning av bröstcancer-patienter ekonomiskt försvarbar?. Svensk Kirurgisk Förenings Förhandlingar, Lund 1982.

Rydén S, Aspegren K, Borgström S, Hafström Lo, Killander D, Landberg T, Möller T, Risholm L, Wiklander O: Adjuvant therapy for premenopausal patients with stage II breast cancer. ECCO 3 - 3rd European Conference on Clinical Oncology and Cancer Nursing, Stockholm 1985; p 157.

Rydén S, Möller T, Hafström LO, Ranstam J, Westrup C, Wiklander O: Adjuvant therapy of breast cancer - compliance and data validity in a multicenter trial. Controlled Clinical Trials 1986;7:290-305.

Rydén S, Fernö M, Borg Å, Hafström L, Möller T, Norgren A: Prognostic significance of estrogen and progesterone receptors in stage II breast cancer. J Surg Oncol 1988;37:221-226.

Early Breast Cancer Trialists’ Collaborative Group: Review of mortality results in randomised trials in early breast cancer. The Lancet 1984;xxx:1204.

Early Breast Cancer Trialists’ Collaborative Group: Effects of adjuvant tamoxifen and of cytotoxic therapy on mortality in early breast cancer. An overview of 61 randomized trials among 28,896 women. N Engl J Med 1988;319:1681-1692.

Early Breast Cancer Trialists’Collaborative Group: Treatment of early breast cancer. Worldwide experience1985-1990. Oxford University Press, Oxford 1990.     

Early Breast Cancer Trialists’ Collaborative Group: Systemic treatment of early breast cancer by hormonal, cytotoxic, or immune therapy. The Lancet 1992;339:1-15+71-85.

Early Breast Cancer Trialists’ Collaborative Group: Effects of radiotherapy and surgery in early breast cancer. N Engl J Med 1995;333:1444-1455.

Early Breast Cancer Trialists’ Collaborative Group: Polychemotherapy for early breast cancer: An overview of the randomised trials. The Lancet 1998;352:930-942.